Package: ToxCrit
Type: Package
Title: Calculates Safety Stopping Boundaries for a Single-Arm Trial
        using Bayes
Version: 1.0
Authors@R: c(person("NCT Trial Center, Heidelberg", 
                email="studienzentrale@nct-heidelberg.de",
                role="aut"),
            person("Lisa-Marie Lanz",
               email="studienzentrale@nct-heidelberg.de", 
               role="cre"))
Author: NCT Trial Center, Heidelberg [aut],
  Lisa-Marie Lanz [cre]
Maintainer: Lisa-Marie Lanz <studienzentrale@nct-heidelberg.de>
Description: Computation of stopping boundaries for a single-arm trial using a
    Bayesian criterion; i.e., for each m<=n (n= total patient number of the 
    trial) the smallest number of observed toxicities is calculated
    leading to the termination of the trial/accrual according to the specified 
    criteria. The probabilities of stopping the trial/accrual at and up until 
    (resp.) the m-th patient (m<=n) is also calculated. This design is more 
    conservative than the frequentist approach (using Clopper Pearson CIs)
    which might be preferred as it concerns safety.See also Aamot et.al.(2010) 
    "Continuous monitoring of toxicity in clinical trials - simulating the risk 
    of stopping prematurely" <doi:10.5414/cpp48476>.
Language: en-US
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.1.2
NeedsCompilation: no
Packaged: 2021-09-30 13:22:12 UTC; Lisa
Repository: CRAN
Date/Publication: 2021-10-01 08:20:08 UTC
Built: R 4.6.0; ; 2025-07-18 05:02:36 UTC; unix
